Steven Roose, M.D. – Conte Center

Dr. Steve Roose, Co-Principal Investigator, Research Training Core, Conte Center for Suicide Prevention

Steven P. Roose, M.D. is Professor of Clinical Psychiatry at the Vagelos College of Physicians and Surgeons, Columbia University, and a Research Psychiatrist at the New York State Psychiatric Institute. He did his undergraduate work at Harvard University and attended medical school at the Mount Sinai School of Medicine. After medical internship, Dr. Roose completed his psychiatric residency at Columbia Presbyterian — New York State Psychiatric Institute and, subsequently, an NIMH-sponsored research fellowship in affective disorders.

He is program director of the T-32 in Research Training for Late-Life Neuropsychiatric Disorders and the T-32 in Research Training for Mood and Anxiety Disorders: From Animal Models to Patients.

Roose is also a graduate of the Center for Psychoanalytic Training and Research, Columbia University, and is Director of the Research Committee at the Columbia Center. Dr. Roose is the Research Training Director for the Conte Center for Suicide Prevention Administrative Core 1.

Research Focus

Dr. Roose’s research has focused on the phenomenology, psychobiology and treatment of affective disorders with a specific concentration on the relationship between cardiovascular disease and depression and the biology and treatment of late-life depression

He has authored or coauthored over 300 articles as well as co-edited or authored seven books.

His research has focused on the phenomenology, psychobiology and treatment of affective disorders, with specific concentration on the relationship between cardiovascular disease and depression, and on the treatment of late-life depression.

Select Publications

1. Roose SP, Laghrissi-Thode F, Kennedy JS, Nelson JC, Bigger JT, Pollock BG, Gaffney A, Narayan M,Finkel MS, McCafferty J,, Gergel I. A comparison of paroxetine to nortriptyline in depressed patients with ischemic heart disease. JAMA 279:287-291, 1998. PMID: 945071

2. Roose SP, Glassman AH, Seidman SN. Relationship between depression and other medical illnesses. JAMA 286(14):1687-1690, 2001. PMID: 11594878

3. Roose SP, Sackeim HA. Clinical Trials in late-life depression revisited. Am J Geriatr Psychiatry 10(5):503-506. 2002. PMID: 12213683

4. Roose SP. Treatment of Depression in Patients with Heart Disease. Biological Psychiatry. 54(3):262-268, 2003. PMID: 12893102

5. Roose SP, Sackeim HA, Krishnan KR, Pollock BG, Alexopoulos G, Lavretsky H, Katz IR, Hakarainen H. Old-Old Depression Study Group. Antidepressant Pharmacotherapy in the treatment of depression in the very old: A randomized, placebo controlled trial. American Journal of Psychiatry. 161(11):2050-2059, 2004.PMID: 15514405

6. Roose SP, Sackeim HA, eds. Late Life Depression. Oxford University Press: New York 2004.

7. Sackheim HA, Roose SP, Lavori PW. Determining the duration of antidepressant treatment: Application of signal detection methodology and the need for duration adaptive designs (DAD). Biological Psychiatry, 59(6):483-92, 2006. PMID: 16517241

8. Sneed JR, Rindskopf D, Steffens DC, Krishnan RR, Roose SP. The vascular depression subtype, evidence of internal validity. Biological Psychiatry. 64(6):491-7. 2008. PMID: 18490003, PMCID: PMC2597784

9. Rutherford BR, Roose SP. A model of placebo response in antidepressant clinical trials. Am J Psychiatry. 20013;170:723-733

10. Roose, S.P., Rutherford, B.R., Wall, M.W., & Thase, M.E. Practicing Evidence Based Medicine in an Era of High Placebo Response: The Number-Needed-to-Treat Reconsidered. In Press, Br J Psychiatry.

11. Brown, P.J., Fieo, R., Roose, S.P., Liu, X., Sneed, J.R., Rutherford, B.R., Devanand, D.P., & Avlund, K. (2014). Frailty and depression in older adults: A high-risk clinical population. Amer J Geriatr Psychiatry, 22(11), 1083-1095.

12. Stanley B, Perez-Rodriquez M, Labouliere C, Roose SP. A Neuroscience-Oriented Research Approach to Borderline Personality Disorder: J Pers Disord. 2018 Feb 22:1-39.

13. Rutherford BR, Taylor WD, Brown PJ, Sneed JR, Roose SP. Biological Aging and the Future of Geriatric Psychiatry. J Gerontol A Biol Sci Med Sci

14. Roose S, Rutherford B, SSRIs and Operative Bleeding Risk: A Review of the Literature. Jour of Clinical Psychpharamacology