J. John Mann, M.D.

Dr. John Mann, Conte Center for Suicide Prevention, Columbia University

J. John Mann is The Paul Janssen Professor of Translational Neuroscience (in Psychiatry and in Radiology) at Columbia University and Director, Molecular Imaging and Neuropathology Division at the New York State Psychiatric Institute. He is a Past President of the Society of Biological Psychiatry, the International Academy of Suicide Research and the American Foundation for Suicide Prevention. He is a Distinguished Life Fellow of the American Psychiatric Association and a Fellow of the American College of Neuropsychopharmacology.

Dr. Mann received his medical degree from the University of Melbourne, and then completed his internship and residency at the Royal Melbourne Hospital. He was trained in Psychiatry and Internal Medicine and has a Doctorate in Neurochemistry. His research employs functional brain imaging, neurochemistry and molecular genetics to probe the causes of depression and suicide. Dr. Mann has published over 794 peer-reviewed papers and edited 11 books on the subjects of the biology and treatment of mood disorders, suicidal behavior and other psychiatric disorders and has been continuously funded by the NIH since 1984. In private practice he specializes in the treatment of mood disorders and has been repeatedly named as America’s and New York Best Doctors by Castle Connolly.

Dr. Mann has received numerous research and teaching awards, including the American Suicide Foundation Research Award, the American Association of Suicidology Louis I. Dublin Award, the New York State Office of Mental Health Research Award, the Klerman Senior Investigator Award from the National Depressive and Manic Depressive Association, the Columbia University Department of Psychiatry Medical Student Teaching Award, the Stengel Award from the International Association for Suicide Prevention, the Morselli Medal from the International Academy of Suicide Research and the Mood Disorders Research Award from the American College of Psychiatrists. He is an Honorary Professor of the University “Ss. Cyril and Methodius”, Skopje, Macedonia. Dr. Mann is the Director of the NIMH Conte Center for Suicide Prevention and Leader of Project 3, PET Neuroimaging in Vivo in Mood Disorders and Suicidal Behavior.

Research Focus

Dr. Mann’s research employs functional brain imaging, neurochemistry and molecular genetics to probe the causes of depression and suicide.

He is an internationally recognized expert on the subjects of the biology and treatment of mood disorders, suicidal behavior and other psychiatric disorders.

Select Publications

Neurobiology of suicidal behavior

Underwood M, Galfalvy H, Hsiung SC, Liu Y, Simpson NR, Bakalian MJ, Rosoklija GB, Dwork AJ, Arango V, Mann JJ. A Stress Protein Based Suicide Prediction Score and Relationship to Reported Early Life Adversity and Recent Life Stress. International Journal of Neuropsychopharmacology. 2023; pyad025. Doi.org/10.1093/ijnp/pyad025.

Zhang D, Deng Y, Kukanja P, Agirre E, Bartosovic M, Dong M, Ma C, Ma S, Su G, Bao S, Liu Y, Xiao Y, Rosoklija GB, Dwork AJ, Mann JJ, Leong KW, Boldrini M, Wang L, Haeussler M, Raphael BJ, Kluger Y, Castelo-Branco G, Fan R. Spatial epigenome–transcriptome co-profiling of mammalian tissues. Nature. 2023. Doi:10.1038/s41586-023-05795-1.

Fan R, Zhang D, Deng Y, Kukanja P, Bartosovic M, Su G, Bao S, Liu Y, Xiao Y, Ma S, Rosoklija G, Dwork A, Mann JJ, Leong K, Boldrini M, Castelo-Branco G. Spatially resolved epigenome-transcriptome co-profiling of mammalian tissues at the cellular level. Research Square. 2022. Doi.org/10.21203/rs.3.rs-1728747/v1.

Buerke M, Galfalvy H, Keilp JG, Sheftall AH, Burke AK, Bridge JA, Mann JJ, Szanto K. Age effects on clinical and neurocognitive risk factors for suicide attempt in depression – Findings from the AFSP lifespan study. J Affect Disord. 2021 Dec 1;295:123-130. doi: 10.1016/j.jad.2021.08.014. Epub 2021 Aug 13. PMID: 34425314; PMCID: PMC8551053.

Mann JJ, Rizk MM. A Brain-Centric Model of Suicidal Behavior. Am J Psychiatry. 2020 Oct 1;177(10):902-916. doi: 10.1176/appi.ajp.2020.20081224. PMID: 32998550; PMCID: PMC7676389.

Holper L, Lan MJ, Brown PJ, Sublette EM, Burke A, Mann JJ. Brain cytochrome-c-oxidase as a marker of mitochondrial function: A pilot study in major depression using NIRS. Depress Anxiety. 2019 Aug;36(8):766-779. doi: 10.1002/da.22913. Epub 2019 May 21. PMID: 31111623; PMCID: PMC6716511.

Stanley B, Michel CA, Galfalvy HC, Keilp JG, Rizk MM, Richardson-Vejlgaard R, Oquendo MA, Mann JJ. Suicidal subtypes, stress responsivity and impulsive aggression. Psychiatry Res. 2019 Oct;280:112486. doi: 10.1016/j.psychres.2019.112486. Epub 2019 Jul 16. PMID: 31376789; PMCID: PMC7027392.

Positron emission tomography in mood disorders and suicidal behavior

Bartlett EA, Zanderigo F, Stanley B, Choo TH, Galfalvy HC, Pantazatos SP, Sublette ME, Miller JM, Oquendo MA, Mann JJ. In vivo serotonin transporter and 1A receptor binding potential and ecological momentary assessment (EMA) of stress in major depression and suicidal behavior. Eur Neuropsychopharmacol. 2023 May;70:1-13. doi: 10.1016/j.euroneuro.2023.01.006. Epub 2023 Feb 11. PMID: 36780841; PMCID: PMC10121874.

Pantazatos SP, Melhem NM, Brent DA, Zanderigo F, Bartlett EA, Lesanpezeshki M, Burke A, Miller JM, Mann JJ. Ventral prefrontal serotonin 1A receptor binding: a neural marker of vulnerability for mood disorder and suicidal behavior? Molecular Psychiatry. 2022. Doi.org/10.1038/s41380-022-01671-y.

Bartlett EA, Zanderigo F, Shieh D, Miller J, Hurley P, Rubin-Falcone H, Oquendo MA, Sublette ME, Ogden RT, Mann JJ. Serotonin Transporter Binding in Major Depressive Disorder: Impact of Serotonin System Anatomy. Molecular Psychiatry. 2022. Doi.org/10.1038/s41380-022-01578-8.

Schneck N, Tu T, Falcone HR, Miller JM, Zanderigo F, Sublette ME, Oquendo MA, Stanley B, Burke A, Ochsner K, Sajda P, John Mann J. Large-scale network dynamics in neural response to emotionally negative stimuli linked to serotonin 1A binding in major depressive disorder. Mol Psychiatry. 2021 Jun;26(6):2393-2401. doi: 10.1038/s41380-020-0733-5. Epub 2020 Apr 30. PMID: 32355333; PMCID: PMC7606327.

Stress and brain biology

Herzog S, Keilp JG, Galfalvy H, Mann JJ, Stanley BH. Attentional control deficits and suicidal ideation variability: An ecological momentary assessment study in major depression. J Affect Disord. 2023 Feb 15;323:819-825. doi: 10.1016/j.jad.2022.12.053. Epub 2022 Dec 19. PMID: 36549341.

Herzog S, Choo TH, Galfalvy H, Mann JJ, Stanley BH. Effect of non-suicidal self-injury on suicidal ideation: real-time monitoring study. Br J Psychiatry. 2022 Aug;221(2):485-487. doi: 10.1192/bjp.2021.225. PMID: 35081996; PMCID: PMC9296595.

Oquendo MA, Galfalvy HC, Choo TH, Kandlur R, Burke AK, Sublette ME, Miller JM, Mann JJ, Stanley BH. Highly variable suicidal ideation: a phenotypic marker for stress induced suicide risk. Mol Psychiatry. 2021 Sep;26(9):5079-5086. doi: 10.1038/s41380-020-0819-0. Epub 2020 Jun 23. PMID: 32576966; PMCID: PMC7755748.

Stanley B, Martínez-Alés G, Gratch I, Rizk M, Galfalvy H, Choo TH, Mann JJ. Coping strategies that reduce suicidal ideation: An ecological momentary assessment study. J Psychiatr Res. 2021 Jan;133:32-37. doi: 10.1016/j.jpsychires.2020.12.012. Epub 2020 Dec 3. PMID: 33307352; PMCID: PMC8659118.

Itzhaky L, Gratch I, Galfalvy H, Keilp JG, Burke AK, Oquendo MA, Mann JJ, Stanley BH. Psychosocial risk factors and outcomes associated with suicide attempts in childhood: A retrospective study. J Psychiatr Res. 2020 Jun;125:129-135. doi: 10.1016/j.jpsychires.2020.03.008. Epub 2020 Mar 18. PMID: 32278224; PMCID: PMC7217666.

Rizk, Mina M et al. “Variability in Suicidal Ideation is Associated with Affective Instability in Suicide Attempters with Borderline Personality Disorder.” Psychiatry vol. 82,2 (2019): 173-178. doi:10.1080/00332747.2019.1600219.

Rizk MM, Galfalvy H, Singh T, Keilp JG, Sublette ME, Oquendo MA, Mann JJ, Stanley B. Toward subtyping of suicidality: Brief suicidal ideation is associated with greater stress response. J Affect Disord. 2018 Apr 1;230:87-92. doi: 10.1016/j.jad.2018.01.012. PMID: 29407544; PMCID: PMC5811401.

Rizk MM, Galfalvy H, Miller JM, Milak M, Parsey R, Grunebaum M, Burke A, Sublette ME, Oquendo MA, Stanley B, Mann JJ. Characteristics of depressed suicide attempters with remitted substance use disorders. J Psychiatr Res. 2021 May;137:572-578. doi: 10.1016/j.jpsychires.2020.10.041. Epub 2020 Oct 30. PMID: 33158553; PMCID: PMC8084874.

Neuroinflammation, Mood Disorders and Suicide

Ganança L, Galfalvy HC, Cisneros-Trujillo S, Basseda Z, Cooper TB, Ren X, Figueira ML, Oquendo MA, Mann JJ, Sublette ME. Relationships between inflammatory markers and suicide risk status in major depression. J Psychiatr Res. 2021 Feb;134:192-199. doi: 10.1016/j.jpsychires.2020.12.029. Epub 2020 Dec 17. PMID: 33388702; PMCID: PMC8830592.

Daray FM, Mann JJ, Sublette ME. How lipids may affect risk for suicidal behavior. J Psychiatr Res. 2018 Sep;104:16-23. doi: 10.1016/j.jpsychires.2018.06.007. Epub 2018 Jun 12. PMID: 29920417; PMCID: PMC6102068.