Elizabeth Sublette, M.D., Ph.D.

Dr. M. Elizabeth Sublette is Associate Professor of Clinical Psychiatry at Columbia University Vagelos College of Physicians and Surgeons and has been Director of the Research Clinic in the Molecular Imaging and Neuropathology Division (M.I.N.D.) for the past 10 years.  Dr. Sublette serves the Conte Center for Suicide Prevention as the Leader of the Clinical Evaluation Core 2 and Project 5, “Stress, Inflammation, Aggression and Emotion Regulation in Suicidal Behavior”.

Research Focus

Dr. Sublette’s research focuses on the neurobiological role of polyunsaturated fatty acids (PUFAs) and other inflammatory elements in mood disorders and suicide risk. She has used a wide range of approaches to characterize PUFAs in this context, including neuroimaging, genetic and epigenetic, and clinical approaches.

Select Publications

1. Annam J, Galfalvy HC, Keilp JG, Simpson N, Huang YY, Nandakumar R, Byrnes A, Nitahara K, Hall A, Stanley B, Mann JJ, Sublette ME. Plasma cytokine and growth factor response to acute psychosocial stress in major depressive disorder. J Psychiatr Res. 2023 Nov 20;169:224-230. doi: 10.1016/j.jpsychires.2023.11.029. Epub ahead of print. PMID: 38043258.

2. Ling J, Keilp JG, Galfalvy HC, Cardino VN, Ahmed A, Burke AK, Fenton JI, Mann JJ, Sublette ME. Plasma Phospholipid Polyunsaturated Fatty Acid Associations with Neurocognition. Nutrients. 2023 Oct 26;15(21):4542.

3. Bartlett EA, Zanderigo F, Stanley B, Choo TH, Galfalvy HC, Pantazatos SP, Sublette ME, Miller JM, Oquendo MA, Mann JJ. In vivo serotonin transporter and 1A receptor binding potential and ecological momentary assessment (EMA) of stress in major depression and suicidal behavior. European Neuropsychopharmacology. 2023 May 1;70:1-3.

4. Rizk MM, Galfalvy H, Miller JM, Milak M, Parsey R, Grunebaum M, Burke A, Sublette ME, Oquendo MA, Stanley B, Mann JJ. Characteristics of depressed suicide attempters with remitted substance use disorders. Journal of psychiatric research. 2021 May 1;137:572-8.

5. Schneck N, Tu T, Falcone HR, Miller JM, Zanderigo F, Sublette ME, Oquendo MA, Stanley B, Burke A, Ochsner K, Sajda P. Large-scale network dynamics in neural response to emotionally negative stimuli linked to serotonin 1A binding in major depressive disorder. Molecular psychiatry. 2021 Jun;26(6):2393-401.

6. Gananca L, Galfalvy HC, Cisneros-Trujillo S, Basseda Z, Cooper TB, Ren X, Figueira ML, Oquendo MA, Mann JJ, Sublette ME. Relationships between inflammatory markers and suicide risk status in major depression. Journal of psychiatric research. 2021 Feb 1;134:192-9.

7. Oquendo MA, Galfalvy HC, Choo TH, Kandlur R, Burke AK, Sublette ME, Miller JM, Mann JJ, Stanley BH. Highly variable suicidal ideation: a phenotypic marker for stress induced suicide risk. Molecular psychiatry. 2021 Sep;26(9):5079-86.

8. Cheung SG, Goldenthal AR, Uhlemann AC, Mann JJ, Miller JM, Sublette ME. Systematic review of gut microbiota and major depression. Frontiers in psychiatry. 2019 Feb 11;10:34.

9. Holper L, Lan MJ, Brown PJ, Sublette EM, Burke A, Mann JJ. Brain cytochrome‐c‐oxidase as a marker of mitochondrial function: A pilot study in major depression using NIRS. Depression and anxiety. 2019 Aug;36(8):766-79.

10. Rizk MM, Galfalvy H, Singh T, Keilp JG, Sublette ME, Oquendo MA, Mann JJ, Stanley B. Toward subtyping of suicidality: brief suicidal ideation is associated with greater stress response. Journal of affective disorders. 2018 Apr 1;230:87-92.

11. Zanderigo F, Kang Y, Kumar D, Nikolopoulou A, Mozley PD, Kothari PJ, He B, Schlyer D, Rapoport SI, Oquendo MA, Vallabhajosula S. [11C] arachidonic acid incorporation measurement in human brain: Optimization for clinical use. Synapse. 2018 Feb;72(2):e22018.

12. Liu JJ, Hezghia A, Shaikh SR, Cenido JF, Stark RE, Mann JJ, Sublette ME. Regulation of monoamine transporters and receptors by lipid microdomains: implications for depression. Neuropsychopharmacology. 2018 Oct;43(11):2165-79.

13. Daray FM, Mann JJ, Sublette ME. How lipids may affect risk for suicidal behavior. Journal of psychiatric research. 2018 Sep 1;104:16-23.

14. Rizk MM, Rubin-Falcone H, Lin X, Keilp JG, Miller JM, Milak MS, Sublette ME, Oquendo MA, Ogden RT, Abdelfadeel NA, Abdelhameed MA. Gray matter volumetric study of major depression and suicidal behavior. Psychiatry Research: Neuroimaging. 2019 Jan 30;283:16-23.